{"id":13628,"date":"2020-08-19T06:53:34","date_gmt":"2020-08-19T04:53:34","guid":{"rendered":"https:\/\/ggba.swiss\/swiss-scientists-revolutionize-fluorescence-microscopy\/"},"modified":"2023-07-04T13:40:04","modified_gmt":"2023-07-04T11:40:04","slug":"swiss-scientists-revolutionize-fluorescence-microscopy","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/en\/swiss-scientists-revolutionize-fluorescence-microscopy\/","title":{"rendered":"Swiss scientists revolutionize fluorescence microscopy"},"content":{"rendered":"<h4>The glass slides used to prepare samples for looking at under a microscope have hardly changed in the nearly 200 years since their invention. Breaking with tradition, two scientists from EPFL\u2019s Institute of Microengineering in Neuch\u00e2tel have developed a new type of microscope slide that enables early-stage diagnosis of some types of cancer.<\/h4>\n<p>Used in millions of labs around the world for microscopic observations, glass slides have the major drawback of reducing usable light by 70%, making many compounds hard or impossible to detect. At EPFL\u2019s <a href=\"https:\/\/sti.epfl.ch\/research\/institutes\/imt\/microengineering-faculty\/\" target=\"_blank\" rel=\"noopener\">Institute of Microengineering<\/a> in Neuch\u00e2tel, materials chemist Rapha\u00ebl Barbey and optical engineer Nicolas Descharmes have developed a new type of glass slide that can boost the amount of light in fluorescence microscopy by a factor of up to 25. This means that \u2013 in an ideal case \u2013 these revolutionary slides would be able to detect the presence of one molecule, where 25 molecules would be needed on conventional slides.<\/p>\n<h4>Unique optical properties<\/h4>\n<p>The new slides have a layered structure that is capable of controlling the electromagnetic environment surrounding the samples. When light is shined on the fluorophores in a sample, they emit more light than they would on a conventional slide, and all of that light is directed towards the microscope\u2019s detector. This results in clearer, faster, better images.<\/p>\n<h4>Enabling early-stage diagnosis<\/h4>\n<p>Descharmes and Barbey\u2019s invention could enable the early-stage diagnosis of some types of cancer and autoimmune diseases, as well as the easier reading and archiving of histopathology slides. The duo is currently working on industrializing the production of their patented technology, in collaboration with <a href=\"https:\/\/www.csem.ch\/Home\" target=\"_blank\" rel=\"noopener\">CSEM<\/a>, the Swiss Center for Electronics and Microtechnology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The glass slides used to prepare samples for looking at under a microscope have hardly changed in the nearly 200 years since their invention. Breaking with tradition, two scientists from EPFL\u2019s Institute of Microengineering in Neuch\u00e2tel have developed a new type of microscope slide that enables early-stage diagnosis of some types of cancer. Used in [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":13629,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[835],"tags":[908,907,909,883],"class_list":["post-13628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-precision-en","tag-diagnostic","tag-engineering","tag-micronano-technology","tag-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Swiss scientists revolutionize fluorescence microscopy - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staging.ggba.swiss\/en\/swiss-scientists-revolutionize-fluorescence-microscopy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Swiss scientists revolutionize fluorescence microscopy - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"The glass slides used to prepare samples for looking at under a microscope have hardly changed in the nearly 200 years since their invention. Breaking with tradition, two scientists from EPFL\u2019s Institute of Microengineering in Neuch\u00e2tel have developed a new type of microscope slide that enables early-stage diagnosis of some types of cancer. 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