{"id":14727,"date":"2022-01-12T07:00:00","date_gmt":"2022-01-12T06:00:00","guid":{"rendered":"https:\/\/ggba.swiss\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/"},"modified":"2023-07-04T13:40:27","modified_gmt":"2023-07-04T11:40:27","slug":"obseva-achieves-positive-results-in-the-treatment-of-endometriosis","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/","title":{"rendered":"ObsEva achieves positive results in the treatment of endometriosis"},"content":{"rendered":"\n

Endometriosis is a disease in which the endometrium (tissue lining the inside of the uterus) is found outside the uterus, where it induces a chronic inflammatory reaction that may result in scar tissue. The most common symptom of endometriosis is pelvic pain, which often correlates to the menstrual cycle.\u00a0<\/p>\n

In the Phase 3 EDELWEISS 3 Trial, two doses were tested, a 200 mg once-daily dose of linzagolix<\/a> in combination with add-back therapy (ABT) and a 75 mg dose of linzagolix without ABT. The 200 mg dose met the co-primary efficacy objectives, demonstrating reductions in dysmenorrhea (DYS) and non-menstrual pelvic pain (NMPP) at 3 months.<\/p>\n

There were statistically significant and clinically meaningful improvements in the first five ranked secondary endpoints at 6 months: dysmenorrhea, non-menstrual pelvic pain, dyschezia, overall pelvic pain, and ability to do daily activities.<\/p>\n

Excellent efficacy suitable for long-term treatment<\/h4>\n

\u201cWhile there have been recent advances in non-surgical endometriosis treatment, there is still a critical need for therapeutic options for women who suffer from this chronic condition,\u201d said Hugh Taylor, MD, Professor and Chair of Obstetrics and Gynecology at Yale University. \u201cOnce daily linzagolix 200 mg with ABT demonstrated excellent efficacy along with minimal changes in bone mineral density, suggesting this dose may be used for long-term treatment. Availability of medical therapies that can be used long-term is important for this typically younger patient population. The demonstration of improvement in dyschezia is of particular interest as this is the first Phase 3 trial of an oral GnRH antagonist to report efficacy in this common and debilitating symptom of endometriosis.\u201d<\/p>\n

The Geneva-based company\u2019s linzagolix candidate has completed clinical trial development for the treatment of heavy menstrual bleeding associated with uterine fibroids and is currently in late-stage clinical development for the treatment of pain associated with endometriosis.\u00a0Similar to its agreement with Organon for its ebopiprant candidate<\/a>, ObsEva<\/a>\u00a0licensed linzagolix from Kissei and retains worldwide commercial rights for the product, excluding Asia.<\/p>\n","protected":false},"excerpt":{"rendered":"

Geneva-based women\u2019s health biopharmaceutical company ObsEva has announced positive topline results from the Phase 3 EDELWEISS 3 trial of linzagolix in women with moderate-to-severe endometriosis-associated pain.<\/p>\n","protected":false},"author":3,"featured_media":14728,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[833],"tags":[912,902,911],"class_list":["post-14727","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life-science","tag-biotech","tag-personalized-medicine","tag-pharma"],"acf":[],"yoast_head":"\nObsEva achieves positive results in the treatment of endometriosis - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ObsEva achieves positive results in the treatment of endometriosis - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Geneva-based women\u2019s health biopharmaceutical company ObsEva has announced positive topline results from the Phase 3 EDELWEISS 3 trial of linzagolix in women with moderate-to-severe endometriosis-associated pain.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Greater Geneva Bern area\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-12T06:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-04T11:40:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/Stomach-Pain-iStock-630x380-1-3.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"630\" \/>\n\t<meta property=\"og:image:height\" content=\"380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mathieu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"mathieu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/\"},\"author\":{\"name\":\"mathieu\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"headline\":\"ObsEva achieves positive results in the treatment of endometriosis\",\"datePublished\":\"2022-01-12T06:00:00+00:00\",\"dateModified\":\"2023-07-04T11:40:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/\"},\"wordCount\":323,\"image\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Stomach-Pain-iStock-630x380-1-3.jpg\",\"keywords\":[\"Biotech\",\"Personalized Medicine\",\"Pharma\"],\"articleSection\":[\"Life sciences\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/\",\"url\":\"https:\/\/staging.ggba.swiss\/en\/obseva-achieves-positive-results-in-the-treatment-of-endometriosis\/\",\"name\":\"ObsEva achieves positive results in the treatment of endometriosis - 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