{"id":37287,"date":"2026-01-19T07:15:02","date_gmt":"2026-01-19T06:15:02","guid":{"rendered":"https:\/\/ggba.swiss\/?p=37287"},"modified":"2026-01-19T07:15:51","modified_gmt":"2026-01-19T06:15:51","slug":"alveolix-contributes-to-first-lung-on-chip-model-using-genetically-identical-human-cells","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/en\/alveolix-contributes-to-first-lung-on-chip-model-using-genetically-identical-human-cells\/","title":{"rendered":"AlveoliX contributes to first lung-on-chip model using genetically identical human cells"},"content":{"rendered":"\n<p>Bern-based <a href=\"https:\/\/www.alveolix.com\/\">AlveoliX<\/a> has contributed to the development of the world\u2019s first human lung-on-chip model built exclusively from genetically identical cells. The breakthrough was achieved in collaboration with researchers at the <a href=\"https:\/\/www.crick.ac.uk\/\">Francis Crick Institute<\/a> and has been published in the scientific journal <em>Science Advances<\/em>.<\/p>\n\n\n\n<p>The new lung-on-chip model recreates human alveoli, the tiny air sacs responsible for gas exchange and a key barrier against respiratory infections such as tuberculosis. Unlike previous organ-on-chip systems, which typically combine patient-derived and commercially sourced cells, the new approach relies entirely on cells derived from induced pluripotent stem cells from a single donor. This allows the model to more accurately reflect individual lung function and disease progression.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Advancing personalized and non-animal respiratory research<\/h4>\n\n\n\n<p>Using a protocol developed by the research team, alveolar epithelial cells and vascular endothelial cells were generated from stem cells and cultured on opposite sides of a thin membrane inside a lung-on-chip device manufactured by AlveoliX. The system is subjected to rhythmic three-dimensional stretching forces that simulate breathing motions, promoting the formation of microvilli and closely replicating the physical environment of human lungs.<\/p>\n\n\n\n<p>To study infection dynamics, immune cells derived from the same donor were added to the chip before introducing tuberculosis bacteria. The model reproduced key features of early-stage infection, including immune cell clustering and progressive breakdown of the air sac barrier.<\/p>\n\n\n\n<p>The study highlights the growing role of organ-on-chip technologies in reducing reliance on animal models and enabling more predictive, human-relevant research. By using genetically identical cells, the platform opens new possibilities for personalized medicine, allowing researchers to investigate how specific genetic backgrounds influence disease progression and treatment response.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Francis Crick Institute and Bern-based AlveoliX have developed the first human lung-on-chip model built entirely from genetically identical cells, opening new perspectives for personalised respiratory disease research.<\/p>\n","protected":false},"author":6,"featured_media":37288,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[833],"tags":[963,926,902,886],"class_list":["post-37287","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life-science","tag-medical-devices","tag-medtech","tag-personalized-medicine","tag-rd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AlveoliX contributes to first lung-on-chip using identical human cells<\/title>\n<meta name=\"description\" content=\"Francis Crick Institute and AlveoliX have developed the first human lung-on-chip model built entirely from genetically identical cells.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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