{"id":10613,"date":"2022-05-04T08:00:07","date_gmt":"2022-05-04T06:00:07","guid":{"rendered":"https:\/\/ggba.swiss\/des-chercheurs-de-berne-ont-mis-au-point-un-test-dallergie-indolore-et-fiable\/"},"modified":"2023-07-04T13:43:55","modified_gmt":"2023-07-04T11:43:55","slug":"des-chercheurs-de-berne-ont-mis-au-point-un-test-dallergie-indolore-et-fiable","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/des-chercheurs-de-berne-ont-mis-au-point-un-test-dallergie-indolore-et-fiable\/","title":{"rendered":"Des chercheurs de Berne ont mis au point un test d’allergie indolore et fiable"},"content":{"rendered":"\n

Bien que les allergies soient tr\u00e8s r\u00e9pandues, leur diagnostic est complexe et, selon le type d’allergie, les perspectives de succ\u00e8s du traitement ne sont pas toujours \u00e9videntes. Jusqu’\u00e0 pr\u00e9sent, les tests cutan\u00e9s \u00e9taient d\u00e9sagr\u00e9ables, longs et associ\u00e9s \u00e0 un certain risque de d\u00e9clencher une r\u00e9ponse allergique trop importante.<\/p>\n

Environ un tiers de la population mondiale souffre d’une ou plusieurs allergies, et cette tendance s’accentue chaque ann\u00e9e. Les sympt\u00f4mes allergiques peuvent aller de la rougeur et du gonflement de la peau, des d\u00e9mangeaisons ou de l’essoufflement au choc anaphylactique et \u00e0 la mort.<\/p>\n

Le diagnostic d’une allergie est complexe : outre les ant\u00e9c\u00e9dents m\u00e9dicaux, des param\u00e8tres de test dont la validit\u00e9 diagnostique est souvent peu claire sont pris en compte et les patients subissent des tests cutan\u00e9s. Les allergies sont trait\u00e9es par le contr\u00f4le des sympt\u00f4mes et, dans les cas graves, par l’immunoth\u00e9rapie. L’immunoth\u00e9rapie n’est pas toujours couronn\u00e9e de succ\u00e8s : \u00e0 l’heure actuelle, il n’existe pas de m\u00e9thode fiable permettant de pr\u00e9dire les probabilit\u00e9s de gu\u00e9rison avant de mettre en place une telle th\u00e9rapie.<\/p>\n

Un groupe de recherche du D\u00e9partement de Recherche Biom\u00e9dicale (DBMR<\/a>) de l’Universit\u00e9 de Berne<\/a> et du Service de Rhumatologie et d’Immunologie de l’Inselspital<\/a>, h\u00f4pital universitaire de Berne, ainsi que l’Institut de Pharmacologie<\/a> de l’Universit\u00e9 de Berne, ont mis au point un test d’allergie qui simplifie consid\u00e9rablement le diagnostic et peut pr\u00e9dire de mani\u00e8re fiable le succ\u00e8s de l’immunoth\u00e9rapie.<\/p>\n

Pour leur nouveau test d’allergie, les chercheurs ont mis au point une nouvelle culture cellulaire in vitro qui, \u00e0 l’aide de quelques techniques de biologie mol\u00e9culaire, peut g\u00e9n\u00e9rer presque n’importe quel nombre souhait\u00e9 de mastocytes matures. Dans le test, ces mastocytes sont mis en contact avec le s\u00e9rum sanguin de personnes allergiques, puis stimul\u00e9s avec les allerg\u00e8nes \u00e0 tester. \u00c0 ce stade, l’activation des cellules peut \u00eatre quantifi\u00e9e tr\u00e8s facilement et rapidement \u00e0 l’aide de la cytom\u00e9trie de flux.<\/p>\n

Un fort potentiel pour des applications multiples<\/h4>\n

Afin de pouvoir r\u00e9aliser un grand nombre de tests, les chercheurs ont mis au point une approche \u00e0 haut d\u00e9bit permettant de mesurer jusqu’\u00e0 36 conditions dans un seul tube \u00e0 essai. \u00ab\u00a0Une personne form\u00e9e peut d\u00e9j\u00e0 effectuer environ 200 tests par jour en utilisant cette proc\u00e9dure, et le processus sera encore optimis\u00e9\u00a0\u00bb, explique Noemi Zb\u00e4ren du DBMR, principale auteure de l’\u00e9tude.<\/p>\n

Selon les chercheurs, le test pr\u00e9sente \u00e9galement un fort potentiel pour le suivi du succ\u00e8s th\u00e9rapeutique et de la dur\u00e9e d’action de nouveaux m\u00e9dicaments contre les allergies dans le cadre d’essais cliniques, ainsi que pour la d\u00e9termination d’\u00e9ventuelles r\u00e9actions allergiques et le contr\u00f4le de la qualit\u00e9 des produits alimentaires.<\/p>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de l’Universit\u00e9 de Berne et de l’Inselspital, l’h\u00f4pital universitaire de Berne, ont mis au point un nouveau test qui simplifie consid\u00e9rablement le diagnostic des allergies et peut pr\u00e9dire de mani\u00e8re fiable le succ\u00e8s d\u2019un traitement.<\/p>\n","protected":false},"author":3,"featured_media":10614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1022,1032,1068],"class_list":["post-10613","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-biotech-fr","tag-diagnostic-fr","tag-personalized-medicine-fr"],"acf":[],"yoast_head":"\nDes chercheurs de Berne ont mis au point un test d'allergie indolore et fiable - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ggba.swiss\/fr\/des-chercheurs-de-berne-ont-mis-au-point-un-test-dallergie-indolore-et-fiable\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Des chercheurs de Berne ont mis au point un test d'allergie indolore et fiable - 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