{"id":10821,"date":"2022-06-27T10:28:51","date_gmt":"2022-06-27T08:28:51","guid":{"rendered":"https:\/\/ggba.swiss\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/"},"modified":"2023-07-04T13:43:59","modified_gmt":"2023-07-04T11:43:59","slug":"un-hydrogel-pour-le-traitement-du-melanome-metastatique","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/","title":{"rendered":"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique"},"content":{"rendered":"\n

Le cancer noir de la peau (m\u00e9lanome) est un cancer malin qui, s’il est diagnostiqu\u00e9 t\u00f4t, peut \u00eatre compl\u00e8tement \u00e9limin\u00e9 avec de bonnes chances de gu\u00e9rison. Les perspectives s’assombrissent toutefois pour les personnes concern\u00e9es lorsque, \u00e0 un stade ult\u00e9rieur de la maladie, des m\u00e9tastases de la tumeur se propagent \u00e0 d’autres organes.<\/p>\n

Au cours des dix derni\u00e8res ann\u00e9es, il est apparu que l’activation du syst\u00e8me immunitaire par des inhibiteurs immunitaires permettait d’obtenir des r\u00e9sultats th\u00e9rapeutiques spectaculaires. \u00ab\u00a0Malheureusement, une bonne moiti\u00e9 des patients ne r\u00e9agit pas \u00e0 ces traitements\u00a0\u00bb, explique Prof. Mirjam Schenk de l’Institut de Pathologie<\/a> de l’Universit\u00e9 de Berne<\/a>. Son laboratoire montre aujourd’hui une voie prometteuse pour lutter contre le cancer noir de la peau \u00e0 l’aide d’un hydrogel d’un nouveau genre.<\/p>\n

Jusqu’\u00e0 pr\u00e9sent, une bact\u00e9rie vivante au pouvoir infectieux att\u00e9nu\u00e9, la Bacillus Calmette-Gu\u00e9rin (BCG), d\u00e9velopp\u00e9e comme vaccin contre la tuberculose, \u00e9tait autoris\u00e9e pour le traitement des m\u00e9lanomes m\u00e9tastatiques de la peau. Bien qu’il ait entra\u00een\u00e9 une r\u00e9gression des tumeurs cutan\u00e9es locales trait\u00e9es directement et parfois retir\u00e9es, il s’est av\u00e9r\u00e9 moins efficace chez les personnes atteintes de m\u00e9tastases dans les organes internes et n’a pas pu am\u00e9liorer de mani\u00e8re significative le taux de survie des patients concern\u00e9s.<\/p>\n

Un r\u00e9sultat d’une grande importance pour la recherche en immuno-oncologie<\/h4>\n

Le groupe de recherche de l\u2019Universit\u00e9 de Berne vient de montrer que les composants de cette bact\u00e9rie sous forme de gel sont plus efficaces pour contr\u00f4ler la croissance tumorale que les bact\u00e9ries BCG vivantes utilis\u00e9es jusqu’\u00e0 pr\u00e9sent.<\/p>\n

En collaboration avec des chercheurs de l’EPFL<\/a> et du Harbor-UCLA Medical Center aux \u00c9tats-Unis, ils ont mis au point un nouveau type d’hydrogel thermosensible, qui peut \u00eatre administr\u00e9 facilement et en une seule fois. Cet hydrogel est liquide \u00e0 temp\u00e9rature ambiante, mais forme un gel visqueux \u00e0 temp\u00e9rature corporelle qui agit ainsi comme un d\u00e9p\u00f4t local et lib\u00e8re en continu des composants de la bact\u00e9rie. Cela entra\u00eene une activation durable du syst\u00e8me immunitaire.<\/p>\n

\u00ab\u00a0L’application locale de l’hydrogel est une option immunoth\u00e9rapeutique efficace et s\u00fbre pour r\u00e9duire la charge m\u00e9tastatique et prolonger la survie des patients atteints de m\u00e9lanome\u00a0\u00bb, a affirm\u00e9 Prof. Schenk. Ces r\u00e9sultats sont d’une grande importance non seulement dans le contexte de la recherche en immuno-oncologie pour le traitement du m\u00e9lanome, mais aussi pour d’autres tumeurs.<\/p>\n

La prochaine \u00e9tape consistera \u00e0 tester l’efficacit\u00e9 du gel chez les patients dans le cadre d’\u00e9tudes cliniques et \u00e0 le comparer aux th\u00e9rapies d\u00e9j\u00e0 autoris\u00e9es.<\/p>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de l’Universit\u00e9 de Berne ont d\u00e9velopp\u00e9 une possibilit\u00e9 de traitement qui active le syst\u00e8me de d\u00e9fense de l’organisme contre le cancer noir de la peau. Des composants d’une bact\u00e9rie sont incorpor\u00e9s dans un gel et appliqu\u00e9s directement dans la zone de la tumeur.<\/p>\n","protected":false},"author":3,"featured_media":10822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1038,1065,1068],"class_list":["post-10821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-education-fr","tag-oncology-fr","tag-personalized-medicine-fr"],"acf":[],"yoast_head":"\nUn hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Des chercheurs de l'Universit\u00e9 de Berne ont d\u00e9velopp\u00e9 une possibilit\u00e9 de traitement qui active le syst\u00e8me de d\u00e9fense de l'organisme contre le cancer noir de la peau. Des composants d'une bact\u00e9rie sont incorpor\u00e9s dans un gel et appliqu\u00e9s directement dans la zone de la tumeur.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\" \/>\n<meta property=\"og:site_name\" content=\"Greater Geneva Bern area\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-27T08:28:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-04T11:43:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"630\" \/>\n\t<meta property=\"og:image:height\" content=\"380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mathieu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"mathieu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\"},\"author\":{\"name\":\"mathieu\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"headline\":\"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique\",\"datePublished\":\"2022-06-27T08:28:51+00:00\",\"dateModified\":\"2023-07-04T11:43:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\"},\"wordCount\":480,\"image\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg\",\"keywords\":[\"Education\",\"Oncology\",\"Personalized Medicine\"],\"articleSection\":[\"Sciences de la vie\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\",\"url\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\",\"name\":\"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique - Greater Geneva Bern area\",\"isPartOf\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg\",\"datePublished\":\"2022-06-27T08:28:51+00:00\",\"dateModified\":\"2023-07-04T11:43:59+00:00\",\"author\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"breadcrumb\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage\",\"url\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg\",\"contentUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg\",\"width\":630,\"height\":380},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/ggba.swiss\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#website\",\"url\":\"https:\/\/staging.ggba.swiss\/en\/\",\"name\":\"Greater Geneva Bern area\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/staging.ggba.swiss\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\",\"name\":\"mathieu\",\"url\":\"https:\/\/ggba.swiss\/fr\/author\/mathieu\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique - Greater Geneva Bern area","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/","og_locale":"fr_FR","og_type":"article","og_title":"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique - Greater Geneva Bern area","og_description":"Des chercheurs de l'Universit\u00e9 de Berne ont d\u00e9velopp\u00e9 une possibilit\u00e9 de traitement qui active le syst\u00e8me de d\u00e9fense de l'organisme contre le cancer noir de la peau. Des composants d'une bact\u00e9rie sont incorpor\u00e9s dans un gel et appliqu\u00e9s directement dans la zone de la tumeur.","og_url":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/","og_site_name":"Greater Geneva Bern area","article_published_time":"2022-06-27T08:28:51+00:00","article_modified_time":"2023-07-04T11:43:59+00:00","og_image":[{"width":630,"height":380,"url":"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg","type":"image\/jpeg"}],"author":"mathieu","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"mathieu","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#article","isPartOf":{"@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/"},"author":{"name":"mathieu","@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab"},"headline":"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique","datePublished":"2022-06-27T08:28:51+00:00","dateModified":"2023-07-04T11:43:59+00:00","mainEntityOfPage":{"@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/"},"wordCount":480,"image":{"@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage"},"thumbnailUrl":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg","keywords":["Education","Oncology","Personalized Medicine"],"articleSection":["Sciences de la vie"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/","url":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/","name":"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique - Greater Geneva Bern area","isPartOf":{"@id":"https:\/\/staging.ggba.swiss\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage"},"image":{"@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage"},"thumbnailUrl":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg","datePublished":"2022-06-27T08:28:51+00:00","dateModified":"2023-07-04T11:43:59+00:00","author":{"@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab"},"breadcrumb":{"@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#primaryimage","url":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg","contentUrl":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/UniBE_Pathology_630x380-2.jpeg","width":630,"height":380},{"@type":"BreadcrumbList","@id":"https:\/\/ggba.swiss\/fr\/un-hydrogel-pour-le-traitement-du-melanome-metastatique\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ggba.swiss\/fr\/"},{"@type":"ListItem","position":2,"name":"Un hydrogel pour le traitement du m\u00e9lanome m\u00e9tastatique"}]},{"@type":"WebSite","@id":"https:\/\/staging.ggba.swiss\/en\/#website","url":"https:\/\/staging.ggba.swiss\/en\/","name":"Greater Geneva Bern area","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/staging.ggba.swiss\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab","name":"mathieu","url":"https:\/\/ggba.swiss\/fr\/author\/mathieu\/"}]}},"_links":{"self":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/10821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/comments?post=10821"}],"version-history":[{"count":1,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/10821\/revisions"}],"predecessor-version":[{"id":18189,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/10821\/revisions\/18189"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/media\/10822"}],"wp:attachment":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/media?parent=10821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/categories?post=10821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/tags?post=10821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}