{"id":11921,"date":"2023-06-12T09:24:24","date_gmt":"2023-06-12T07:24:24","guid":{"rendered":"https:\/\/ggba.swiss\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/"},"modified":"2023-07-04T13:44:20","modified_gmt":"2023-07-04T11:44:20","slug":"percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/","title":{"rendered":"Perc\u00e9e dans le traitement du cancer de la prostate \u00e0 l’Universit\u00e9 de Berne"},"content":{"rendered":"\n

Le cancer de la prostate est le cancer non-cutan\u00e9 le plus courant chez les hommes dans le monde, avec environ un homme sur six diagnostiqu\u00e9 au cours de sa vie. Globalement, plus de 375\u2019000 patients succombent \u00e0 cette maladie chaque ann\u00e9e. Les strat\u00e9gies th\u00e9rapeutiques actuelles \u00e9chouent souvent en raison du d\u00e9veloppement de la r\u00e9sistance des tumeurs, soulignant le besoin urgent de th\u00e9rapies innovantes.<\/p>\n

L’effort conjoint des chercheurs dirig\u00e9 par Mark Rubin du D\u00e9partement pour la recherche biom\u00e9dicale (DBMR<\/a>) \u00e0 l’Universit\u00e9 de Berne<\/a> et Rahul Kanadia de l’Universit\u00e9 du Connecticut, a maintenant identifi\u00e9 une vuln\u00e9rabilit\u00e9 auparavant inconnue dans les cellules du cancer de la prostate, qui est \u00e9galement soup\u00e7onn\u00e9e d’exister dans d’autres cellules canc\u00e9reuses.<\/p>\n

Les chercheurs ont concentr\u00e9 leur attention sur une machine mol\u00e9culaire particuli\u00e8re appel\u00e9e spliceosome. Le spliceosome joue un r\u00f4le pivot dans la conversion des g\u00e8nes en prot\u00e9ines, un processus connu sous le nom d’\u00e9pissage, qui est essentiel pour la croissance cellulaire, un processus qui d\u00e9raille dans le cancer.<\/p>\n

\u00ab\u00a0En travaillant sur cette zone, nous avons trouv\u00e9 des preuves significatives pointant vers le r\u00f4le central du petit spliceosome dans le cancer,\u00a0\u00bb a expliqu\u00e9 Rahul Kanadia, co-auteur de l’\u00e9tude de l’Universit\u00e9 du Connecticut. Ils ont d\u00e9couvert qu’un composant sp\u00e9cifique du petit spliceosome \u00e9tait significativement augment\u00e9 dans le cancer de la prostate avanc\u00e9, sugg\u00e9rant que les cellules canc\u00e9reuses pourraient stimuler la croissance cellulaire incontr\u00f4l\u00e9e en activant le petit spliceosome par l’interm\u00e9diaire de ce composant.<\/p>\n

Une \u00e9tape importante dans la th\u00e9rapie contre le cancer<\/h4>\n

L’\u00e9quipe a confirm\u00e9 sa th\u00e9orie \u00e0 l’aide de mod\u00e8les de test de laboratoire, y compris des cultures cellulaires 2D et des organo\u00efdes, de minuscules organes cultiv\u00e9s en laboratoire sur la base d’\u00e9chantillons de patients. L’inhibition de ce composant sp\u00e9cifique a entra\u00een\u00e9 une r\u00e9duction plus significative de la croissance du cancer de la prostate que les th\u00e9rapies standard actuelles, marquant une perc\u00e9e sans pr\u00e9c\u00e9dent dans la th\u00e9rapie contre le cancer.<\/p>\n

\u00ab\u00a0Cette d\u00e9couverte est un potentiel game changer<\/em> dans le d\u00e9veloppement de th\u00e9rapies combin\u00e9es plus efficaces et cibl\u00e9es pour des cancers tels que le cancer de la prostate et potentiellement d’autres types. Nous visons \u00e0 approfondir cela dans les ann\u00e9es \u00e0 venir,\u00a0\u00bb a d\u00e9clar\u00e9 Mark Rubin, qui a \u00e9galement r\u00e9v\u00e9l\u00e9 qu’ils ont d\u00e9pos\u00e9 une demande de brevet.<\/p>\n

Cette recherche r\u00e9volutionnaire a re\u00e7u un financement de USD 1 million de la Fondation am\u00e9ricaine du cancer de la prostate (PCF<\/a>) dans le cadre du Igor Tulchinsky-Leerom Segal-PCF Challenge Award 2022. Howard R. Soule, directeur scientifique en chef de la PCF, a f\u00e9licit\u00e9 l’\u00e9quipe de recherche, d\u00e9clarant: \u00ab\u00a0C\u2019est avec fiert\u00e9 que nous soutenons leur travail pour nous rapprocher de notre mission d’\u00e9liminer la mort et la souffrance du cancer de la prostate.\u00a0\u00bb Cette d\u00e9couverte pionni\u00e8re pourrait en effet repr\u00e9senter une \u00e9tape importante dans la th\u00e9rapie contre le cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dans un tournant dans le monde de la th\u00e9rapie contre le cancer, des chercheurs de l’Universit\u00e9 de Berne, de l’Inselspital Bern et de l’Universit\u00e9 du Connecticut ont r\u00e9alis\u00e9 une perc\u00e9e significative dans la lutte contre le cancer de la prostate.<\/p>\n","protected":false},"author":3,"featured_media":11922,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1065,1068],"class_list":["post-11921","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-oncology-fr","tag-personalized-medicine-fr"],"acf":[],"yoast_head":"\nPerc\u00e9e dans le traitement du cancer de la prostate \u00e0 l'Universit\u00e9 de Berne - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Perc\u00e9e dans le traitement du cancer de la prostate \u00e0 l'Universit\u00e9 de Berne - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Dans un tournant dans le monde de la th\u00e9rapie contre le cancer, des chercheurs de l'Universit\u00e9 de Berne, de l'Inselspital Bern et de l'Universit\u00e9 du Connecticut ont r\u00e9alis\u00e9 une perc\u00e9e significative dans la lutte contre le cancer de la prostate.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/\" \/>\n<meta property=\"og:site_name\" content=\"Greater Geneva Bern area\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-12T07:24:24+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-04T11:44:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/ProstateCancer-630x380-1-2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"630\" \/>\n\t<meta property=\"og:image:height\" content=\"380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mathieu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"mathieu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/\"},\"author\":{\"name\":\"mathieu\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"headline\":\"Perc\u00e9e dans le traitement du cancer de la prostate \u00e0 l’Universit\u00e9 de Berne\",\"datePublished\":\"2023-06-12T07:24:24+00:00\",\"dateModified\":\"2023-07-04T11:44:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/\"},\"wordCount\":539,\"image\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/ProstateCancer-630x380-1-2.jpeg\",\"keywords\":[\"Oncology\",\"Personalized Medicine\"],\"articleSection\":[\"Sciences de la vie\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/\",\"url\":\"https:\/\/ggba.swiss\/fr\/percee-dans-le-traitement-du-cancer-de-la-prostate-a-luniversite-de-berne\/\",\"name\":\"Perc\u00e9e dans le traitement du cancer de la prostate \u00e0 l'Universit\u00e9 de Berne - 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