{"id":11929,"date":"2023-06-13T08:56:40","date_gmt":"2023-06-13T06:56:40","guid":{"rendered":"https:\/\/ggba.swiss\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/"},"modified":"2023-07-04T13:44:20","modified_gmt":"2023-07-04T11:44:20","slug":"un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/","title":{"rendered":"Un vaccin r\u00e9volutionnaire \u00e0 base d’ARNm contre le m\u00e9lanome test\u00e9 \u00e0 Gen\u00e8ve"},"content":{"rendered":"\n

Un vaccin prometteur \u00e0 ARNm d\u00e9velopp\u00e9 par Moderna, dont l’efficacit\u00e9 contre certains cas de m\u00e9lanome a \u00e9t\u00e9 confirm\u00e9e, sera bient\u00f4t test\u00e9 aux H\u00f4pitaux Universitaires de Gen\u00e8ve (HUG<\/a>). Cette technologie ARNm est qualifi\u00e9e de \u00ab\u00a0petite r\u00e9volution\u00a0\u00bb dans le domaine de la vaccinologie anticanc\u00e9reuse par le chef du service d’oncologie des HUG, Olivier Michielin. Le d\u00e9but de l’essai clinique est pr\u00e9vu pour l’\u00e9t\u00e9 ou l’automne 2023.<\/p>\n

Les HUG, ainsi que peut-\u00eatre trois autres sites en Suisse al\u00e9manique, participeront \u00e0 cet essai critique de phase 3 \u00e0 l’\u00e9chelle mondiale. L’objectif est de proposer le traitement combin\u00e9 du vaccin ARNm et de l’immunoth\u00e9rapie aux patients pr\u00e9sentant un risque important de r\u00e9cidive.<\/p>\n

Michielin a parl\u00e9 de l’essai \u00e0 la suite de la plus grande conf\u00e9rence annuelle sur le cancer organis\u00e9e d\u00e9but juin \u00e0 Chicago par l’American Society of Clinical Oncology (Soci\u00e9t\u00e9 am\u00e9ricaine d’oncologie clinique). Au cours de cette conf\u00e9rence, les r\u00e9sultats les plus r\u00e9cents sur le vaccin ARNm ont \u00e9t\u00e9 pr\u00e9sent\u00e9s. Les r\u00e9sultats sugg\u00e8rent une r\u00e9duction significative des r\u00e9cidives chez les personnes diagnostiqu\u00e9es avec un cancer de la peau lorsque le vaccin est administr\u00e9 en conjonction avec le m\u00e9dicament anticanc\u00e9reux Keytruda, d\u00e9velopp\u00e9 par Merck.<\/p>\n

Selon M. Michielin, ces r\u00e9sultats sont \u00ab\u00a0extr\u00eamement impressionnants\u00a0\u00bb. Le risque de r\u00e9cidives m\u00e9tastatiques dans des organes autres que la peau est r\u00e9duit de 65 % par rapport \u00e0 l’immunoth\u00e9rapie seule, qui r\u00e9duisait d\u00e9j\u00e0 ce risque d’environ 40 %. \u00ab\u00a0Nous ne nous attendions pas \u00e0 voir un jour de tels chiffres. L’excitation \u00e9tait palpable lors de la conf\u00e9rence\u00a0\u00bb, a comment\u00e9 M. Michielin.<\/p>\n

Un bouleversement dans les th\u00e9rapies personnalis\u00e9es contre le cancer<\/h4>\n

La technologie de l’ARNm est consid\u00e9r\u00e9e comme r\u00e9volutionnaire dans le domaine de la vaccinologie anticanc\u00e9reuse. Pour la premi\u00e8re fois, elle permet de cibler de nombreuses mutations sp\u00e9cifiques propres \u00e0 chaque individu. Cette approche r\u00e9volutionnaire est consid\u00e9r\u00e9e comme un changement dans la m\u00e9decine personnalis\u00e9e, offrant une nouvelle fa\u00e7on potentielle de lutter contre divers types de cancer.<\/p>\n

Un autre avantage est le faible niveau de toxicit\u00e9 de ce type de vaccin. Cela en fait une option th\u00e9rapeutique viable pour les patients ayant subi une greffe, un groupe pour lequel l’immunoth\u00e9rapie n’est souvent pas propos\u00e9e en raison du risque de rejet du greffon.<\/p>\n

Cet essai \u00e0 venir pr\u00e9sente donc un potentiel important pour l’avancement des traitements contre le cancer, en particulier contre le m\u00e9lanome. Les r\u00e9sultats de cet essai pourraient changer la fa\u00e7on dont nous comprenons, ciblons et traitons non seulement le m\u00e9lanome, mais aussi d’autres formes de cancer, marquant ainsi une nouvelle \u00e8re dans le traitement du cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"

Le vaccin \u00e0 ARNm de Moderna contre le m\u00e9lanome sera test\u00e9 aux H\u00f4pitaux Universitaires de Gen\u00e8ve en 2023. Le vaccin, combin\u00e9 \u00e0 l’immunoth\u00e9rapie, pourrait r\u00e9duire de mani\u00e8re significative la r\u00e9currence du cancer.<\/p>\n","protected":false},"author":3,"featured_media":11930,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1027,1065,1068],"class_list":["post-11929","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-covid-19-fr","tag-oncology-fr","tag-personalized-medicine-fr"],"acf":[],"yoast_head":"\nUn vaccin r\u00e9volutionnaire \u00e0 base d'ARNm contre le m\u00e9lanome test\u00e9 \u00e0 Gen\u00e8ve - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un vaccin r\u00e9volutionnaire \u00e0 base d'ARNm contre le m\u00e9lanome test\u00e9 \u00e0 Gen\u00e8ve - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Le vaccin \u00e0 ARNm de Moderna contre le m\u00e9lanome sera test\u00e9 aux H\u00f4pitaux Universitaires de Gen\u00e8ve en 2023. Le vaccin, combin\u00e9 \u00e0 l'immunoth\u00e9rapie, pourrait r\u00e9duire de mani\u00e8re significative la r\u00e9currence du cancer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/\" \/>\n<meta property=\"og:site_name\" content=\"Greater Geneva Bern area\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-13T06:56:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-04T11:44:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/HUG-Geneve-630x380-1-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"630\" \/>\n\t<meta property=\"og:image:height\" content=\"380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mathieu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"mathieu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/\"},\"author\":{\"name\":\"mathieu\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"headline\":\"Un vaccin r\u00e9volutionnaire \u00e0 base d’ARNm contre le m\u00e9lanome test\u00e9 \u00e0 Gen\u00e8ve\",\"datePublished\":\"2023-06-13T06:56:40+00:00\",\"dateModified\":\"2023-07-04T11:44:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/\"},\"wordCount\":498,\"image\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/HUG-Geneve-630x380-1-2.jpg\",\"keywords\":[\"Covid-19\",\"Oncology\",\"Personalized Medicine\"],\"articleSection\":[\"Sciences de la vie\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/\",\"url\":\"https:\/\/ggba.swiss\/fr\/un-vaccin-revolutionnaire-a-base-darnm-contre-le-melanome-teste-a-geneve\/\",\"name\":\"Un vaccin r\u00e9volutionnaire \u00e0 base d'ARNm contre le m\u00e9lanome test\u00e9 \u00e0 Gen\u00e8ve - 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