{"id":35429,"date":"2025-09-09T09:38:41","date_gmt":"2025-09-09T07:38:41","guid":{"rendered":"https:\/\/ggba.swiss\/csem-and-cellvie-automate-mitochondria-isolation-for-clinical-use\/"},"modified":"2025-09-09T09:40:48","modified_gmt":"2025-09-09T07:40:48","slug":"le-csem-et-cellvie-automatisent-lisolement-des-mitochondries-pour-un-usage-clinique","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/le-csem-et-cellvie-automatisent-lisolement-des-mitochondries-pour-un-usage-clinique\/","title":{"rendered":"Le CSEM et cellvie automatisent l\u2019isolement des mitochondries pour un usage clinique"},"content":{"rendered":"\n

La start-up cellvie<\/a> et le Centre Suisse d\u2019Electronique et de Microtechnique (CSEM<\/a>) ont annonc\u00e9 une avanc\u00e9e majeure dans le d\u00e9veloppement de la transplantation mitochondriale th\u00e9rapeutique (TMT). Ensemble, les partenaires ont cr\u00e9\u00e9 une solution ferm\u00e9e et automatis\u00e9e pour isoler les mitochondries \u00e0 grande \u00e9chelle, une \u00e9tape critique pour rapprocher cette th\u00e9rapie novatrice des patients.<\/p>\n\n\n\n

Les l\u00e9sions d\u2019isch\u00e9mie-reperfusion (IRI) surviennent lorsque le flux sanguin revient dans un tissu apr\u00e8s une obstruction temporaire et constituent une cause majeure de mortalit\u00e9 dans le monde. Elles sont associ\u00e9es \u00e0 des pathologies telles que les crises cardiaques, les AVC, les transplantations d\u2019organes et les longues interventions chirurgicales. En l\u2019absence de traitement sp\u00e9cifique, les soins actuels visent surtout \u00e0 limiter les dommages. Cellvie innove en utilisant des mitochondries actives, qui sont les structures productrices d\u2019\u00e9nergie des cellules, et administr\u00e9es pendant ou apr\u00e8s la reperfusion pour restaurer le m\u00e9tabolisme \u00e9nerg\u00e9tique et pr\u00e9venir la mort cellulaire.<\/p>\n\n\n\n

Automatiser un processus complexe<\/h4>\n\n\n\n

L\u2019un des principaux obstacles \u00e0 la mise en \u0153uvre clinique r\u00e9sidait dans le processus de fabrication. Le protocole original, con\u00e7u par le cofondateur de cellvie, le Dr James McCully, impliquait de nombreuses \u00e9tapes manuelles et manipulations ouvertes, limitant la reproductibilit\u00e9 et l\u2019\u00e9volutivit\u00e9. Avec le soutien d\u2019une bourse Innosuisse de plus de CHF 700\u2019000, le CSEM et cellvie ont repens\u00e9 le processus pour en faire un flux de travail automatis\u00e9 unique, conforme aux normes de Bonnes Pratiques de Fabrication (GMP).<\/p>\n\n\n\n

\u00ab Mettre en place un syst\u00e8me robuste et \u00e9volutif pour l\u2019isolement des mitochondries est essentiel pour garantir leur fonctionnalit\u00e9 bio\u00e9nerg\u00e9tique et leur s\u00e9curit\u00e9, et ouvre la voie \u00e0 l\u2019arriv\u00e9e en clinique de th\u00e9rapies mitochondriales r\u00e9volutionnaires \u00bb, a d\u00e9clar\u00e9 Charlotte Fonta, Ing\u00e9nieure R&D senior au CSEM.<\/p>\n\n\n\n

Le Dr Martijn Brugman, COO de cellvie, a soulign\u00e9 que le syst\u00e8me avait \u00e9t\u00e9 con\u00e7u d\u00e8s le d\u00e9part dans le respect des normes GMP, permettant ainsi des pr\u00e9parations \u00e0 haut volume et \u00e0 des co\u00fbts nettement r\u00e9duits.<\/p>\n\n\n\n

Vers la traduction clinique<\/strong><\/p>\n\n\n\n

Le processus d\u00e9sormais valid\u00e9, la prochaine \u00e9tape consistera \u00e0 transf\u00e9rer la plateforme \u00e0 un CDMO (Contract Development and Manufacturing Organization) pour les essais cliniques de Phase I. \u00ab Il s\u2019agit d\u2019une pi\u00e8ce ma\u00eetresse pour la traduction clinique \u00bb, a expliqu\u00e9 Alexander Schueller, fondateur et CEO de cellvie. \u00ab Gr\u00e2ce au projet Innosuisse et aux efforts soutenus des \u00e9quipes, nous disposons aujourd\u2019hui d\u2019un point de d\u00e9part solide. \u00bb<\/p>\n","protected":false},"excerpt":{"rendered":"

Une nouvelle plateforme automatis\u00e9e d\u00e9velopp\u00e9e par cellvie et le CSEM simplifie l\u2019isolement des mitochondries, faisant progresser la transplantation th\u00e9rapeutique pour les l\u00e9sions d\u2019isch\u00e9mie-reperfusion.<\/p>\n","protected":false},"author":6,"featured_media":35426,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1238,1169,1181,1142,1168],"class_list":["post-35429","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-bioinformatics-fr-2","tag-biotech-fr-2","tag-medical-devices-fr","tag-rd-fr-2","tag-technology-park-fr-2"],"acf":[],"yoast_head":"\nLe CSEM et cellvie automatisent l\u2019isolement des mitochondries<\/title>\n<meta name=\"description\" content=\"Une nouvelle plateforme automatis\u00e9e 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