{"id":36762,"date":"2025-12-02T11:36:41","date_gmt":"2025-12-02T10:36:41","guid":{"rendered":"https:\/\/ggba.swiss\/chuv-researchers-develop-new-method-to-study-autoimmune-diseases\/"},"modified":"2025-12-02T11:38:43","modified_gmt":"2025-12-02T10:38:43","slug":"des-chercheurs-du-chuv-developpent-une-nouvelle-methode-pour-etudier-les-maladies-auto-immunes","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/des-chercheurs-du-chuv-developpent-une-nouvelle-methode-pour-etudier-les-maladies-auto-immunes\/","title":{"rendered":"Des chercheurs du CHUV d\u00e9veloppent une nouvelle m\u00e9thode pour \u00e9tudier les maladies auto-immunes"},"content":{"rendered":"\n

Des chercheurs du CHUV<\/a> ont valid\u00e9 une nouvelle approche permettant d\u2019\u00e9tudier les m\u00e9canismes des maladies auto-immunes dans des organes o\u00f9 les biopsies ne sont pas r\u00e9alisables, comme le cerveau. Publi\u00e9e dans Nature Communications<\/a><\/em>, cette m\u00e9thode offre la possibilit\u00e9 d\u2019observer directement les interactions entre cellules immunitaires et neurones d\u00e9riv\u00e9s de patients, am\u00e9liorant ainsi la compr\u00e9hension des troubles neuro-immunologiques.<\/p>\n\n\n\n

Les maladies auto-immunes surviennent lorsque le syst\u00e8me immunitaire attaque par erreur des tissus sains et peuvent toucher divers organes, des articulations au syst\u00e8me digestif, jusqu\u2019au syst\u00e8me nerveux central. Comprendre le comportement des cellules immunitaires dans des tissus difficiles d\u2019acc\u00e8s repr\u00e9sente un d\u00e9fi de longue date : si les mod\u00e8les animaux apportent des informations pr\u00e9cieuses, ils ne reproduisent pas enti\u00e8rement la biologie humaine, et le pr\u00e9l\u00e8vement direct d\u2019organes tels que le cerveau n\u2019est pas envisageable \u00e0 des fins de recherche.<\/p>\n\n\n\n

Pour contourner ces limites, l\u2019\u00e9quipe dirig\u00e9e par le professeur Renaud Du Pasquier, Chef du Service de neurologie et du Laboratoire de neuro-immunologie du CHUV, a eu recours \u00e0 la technologie des cellules souches pluripotentes induites (hiPSC). Introduite au laboratoire en 2012, cette technique consiste \u00e0 reprogrammer des cellules pr\u00e9lev\u00e9es dans un \u00e9chantillon sanguin ou cutan\u00e9 pour les transformer en cellules souches, qui peuvent ensuite \u00eatre diff\u00e9renci\u00e9es en neurones ou en d\u2019autres types cellulaires. Les chercheurs peuvent ainsi observer les interactions entre les cellules immunitaires d\u2019un patient et des neurones g\u00e9n\u00e9tiquement identiques issus de ses propres tissus.<\/p>\n\n\n\n

Vers des th\u00e9rapies plus cibl\u00e9es<\/h4>\n\n\n\n

Appliqu\u00e9e \u00e0 l\u2019enc\u00e9phalite auto-immune, une maladie inflammatoire du cerveau, la m\u00e9thode a permis de d\u00e9montrer que les lymphocytes T CD8+, souvent appel\u00e9s \u00ab cellules tueuses \u00bb, ciblent directement les neurones. Gr\u00e2ce au s\u00e9quen\u00e7age d\u2019ARN monocellulaire, l\u2019\u00e9quipe a \u00e9galement identifi\u00e9 une sous-population sp\u00e9cifique de lymphocytes T CD8+ r\u00e9gulateurs, normalement charg\u00e9s de limiter la r\u00e9ponse immunitaire, qui semble jouer un r\u00f4le central dans la pathologie.<\/p>\n\n\n\n

Ces r\u00e9sultats valident un nouveau cadre d\u2019\u00e9tude des maladies auto-immunes c\u00e9r\u00e9brales et pourraient \u00eatre transpos\u00e9s \u00e0 d\u2019autres organes difficiles \u00e0 analyser, comme le pancr\u00e9as ou le c\u0153ur. L\u2019\u00e9quipe du CHUV applique d\u00e9j\u00e0 cette approche \u00e0 la scl\u00e9rose en plaques, qui touche environ 18’000 personnes en Suisse. Les premiers r\u00e9sultats sugg\u00e8rent que cette m\u00e9thode pourrait am\u00e9liorer la compr\u00e9hension de la progression de la maladie et contribuer au d\u00e9veloppement de strat\u00e9gies th\u00e9rapeutiques plus cibl\u00e9es.<\/p>\n","protected":false},"excerpt":{"rendered":"

Les chercheurs du CHUV ont valid\u00e9 une nouvelle m\u00e9thode bas\u00e9e sur des cellules souches pour \u00e9tudier les m\u00e9canismes des maladies auto-immunes dans des organes difficiles d\u2019acc\u00e8s, comme le cerveau, ouvrant la voie \u00e0 de nouvelles avanc\u00e9es dans des pathologies telles que l\u2019enc\u00e9phalite auto-immune et la scl\u00e9rose en plaques.<\/p>\n","protected":false},"author":6,"featured_media":36759,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1169,1188,1140,1142],"class_list":["post-36762","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-biotech-fr-2","tag-healthcare-fr-2","tag-oncology-fr-2","tag-rd-fr-2"],"acf":[],"yoast_head":"\nUne nouvelle m\u00e9thode pour \u00e9tudier les maladies 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