{"id":9626,"date":"2021-03-10T12:39:45","date_gmt":"2021-03-10T11:39:45","guid":{"rendered":"https:\/\/ggba.swiss\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/"},"modified":"2023-07-04T13:43:34","modified_gmt":"2023-07-04T11:43:34","slug":"chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer","status":"publish","type":"post","link":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/","title":{"rendered":"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer"},"content":{"rendered":"

Rien que dans l’UE, 78\u2019800 hommes sont morts du cancer de la prostate en 2020. Si les tumeurs d\u00e9couvertes \u00e0 un stade pr\u00e9coce peuvent souvent \u00eatre compl\u00e8tement \u00e9limin\u00e9es par la chirurgie et la radioth\u00e9rapie, les chances de succ\u00e8s du traitement sont r\u00e9duites si le cancer continue \u00e0 se m\u00e9tastaser. \u00c0 l’heure actuelle, les m\u00e9decins ne peuvent pas pr\u00e9dire la r\u00e9action aux m\u00e9dicaments ou la r\u00e9sistance au traitement chez les patients.<\/p>\n

Une \u00e9quipe du Laboratoire de recherche en urologie du D\u00e9partement de recherche biom\u00e9dicale (DBMR<\/a>) de l’Universit\u00e9 de Berne<\/a> et de l’Inselspital<\/a> a d\u00e9velopp\u00e9 une nouvelle approche pour la g\u00e9n\u00e9ration d’organo\u00efdes pour le cancer de la prostate pouvant contribuer \u00e0 \u00e9valuer la r\u00e9ponse \u00e0 la th\u00e9rapie.<\/p>\n

L’\u00e9quipe a d’abord g\u00e9n\u00e9r\u00e9 une nouvelle x\u00e9nogreffe \u00e0 un stade pr\u00e9coce, d\u00e9riv\u00e9e du patient et na\u00efve sur le plan th\u00e9rapeutique, puis a test\u00e9 74 m\u00e9dicaments diff\u00e9rents sur des organo\u00efdes provenant de ce mod\u00e8le et d’autres mod\u00e8les tumoraux exp\u00e9rimentaux, identifiant 13 compos\u00e9s qui r\u00e9duisaient la viabilit\u00e9 des cellules canc\u00e9reuses de la prostate.<\/p>\n

L’efficacit\u00e9 de ces compos\u00e9s a ensuite \u00e9t\u00e9 test\u00e9e sur les organo\u00efdes de cinq patients atteints d’un cancer de la prostate – deux avec des tumeurs de stade pr\u00e9coce et trois avec des tumeurs m\u00e9tastatiques avanc\u00e9es. Il est int\u00e9ressant de noter que parmi les succ\u00e8s, le ponatinib, approuv\u00e9 jusqu’\u00e0 pr\u00e9sent pour le traitement de la leuc\u00e9mie, s’est r\u00e9v\u00e9l\u00e9 particuli\u00e8rement efficace pour r\u00e9duire la viabilit\u00e9 des organo\u00efdes et la croissance des tumeurs in vivo.<\/p>\n

Vers une m\u00e9decine davantage personnalis\u00e9e<\/h4>\n

\u00ab\u00a0Dans mon activit\u00e9 clinique, je suis r\u00e9guli\u00e8rement confront\u00e9 \u00e0 des tumeurs qui ne r\u00e9pondent pas \u00e0 la th\u00e9rapie ou pour lesquelles nous ne savons pas quelle th\u00e9rapie utiliser\u00a0\u00bb, d\u00e9clare le professeur Thalmann du d\u00e9partement d’urologie de l’Inselspital. \u00ab\u00a0C’est un pas de plus vers une m\u00e9decine personnalis\u00e9e, o\u00f9 nous pourrions \u00eatre en mesure d’adapter le traitement \u00e0 la tumeur au cours de la maladie et de mieux en comprendre sa nature.\u00a0\u00bb<\/p>\n

Avec cette approche, les chercheurs bernois esp\u00e8rent traiter les patients plus efficacement, avec moins d’effets secondaires et des co\u00fbts r\u00e9duits.<\/p>\n","protected":false},"excerpt":{"rendered":"

Des scientifiques de l’Universit\u00e9 et de l’Inselspital de Berne ont \u00e9tabli des mod\u00e8les de culture organo\u00efde \u00e0 partir de biopsies de tumeurs de la prostate. Il s’agit de petits groupes de cellules qui peuvent \u00eatre utilis\u00e9s pour tester l’efficacit\u00e9 de divers m\u00e9dicaments, permettant ainsi de d\u00e9terminer quel traitement sera le plus b\u00e9n\u00e9fique \u00e0 chaque patient.<\/p>\n","protected":false},"author":3,"featured_media":9627,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[843],"tags":[1038,1065,1068],"class_list":["post-9626","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciences-de-la-vie","tag-education-fr","tag-oncology-fr","tag-personalized-medicine-fr"],"acf":[],"yoast_head":"\nDes chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Des scientifiques de l'Universit\u00e9 et de l'Inselspital de Berne ont \u00e9tabli des mod\u00e8les de culture organo\u00efde \u00e0 partir de biopsies de tumeurs de la prostate. Il s'agit de petits groupes de cellules qui peuvent \u00eatre utilis\u00e9s pour tester l'efficacit\u00e9 de divers m\u00e9dicaments, permettant ainsi de d\u00e9terminer quel traitement sera le plus b\u00e9n\u00e9fique \u00e0 chaque patient.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Greater Geneva Bern area\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-10T11:39:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-04T11:43:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"630\" \/>\n\t<meta property=\"og:image:height\" content=\"380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mathieu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"mathieu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\"},\"author\":{\"name\":\"mathieu\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"headline\":\"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer\",\"datePublished\":\"2021-03-10T11:39:45+00:00\",\"dateModified\":\"2023-07-04T11:43:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\"},\"wordCount\":424,\"image\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg\",\"keywords\":[\"Education\",\"Oncology\",\"Personalized Medicine\"],\"articleSection\":[\"Sciences de la vie\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\",\"url\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\",\"name\":\"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer - Greater Geneva Bern area\",\"isPartOf\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg\",\"datePublished\":\"2021-03-10T11:39:45+00:00\",\"dateModified\":\"2023-07-04T11:43:34+00:00\",\"author\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\"},\"breadcrumb\":{\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage\",\"url\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg\",\"contentUrl\":\"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg\",\"width\":630,\"height\":380},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/ggba.swiss\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#website\",\"url\":\"https:\/\/staging.ggba.swiss\/en\/\",\"name\":\"Greater Geneva Bern area\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/staging.ggba.swiss\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab\",\"name\":\"mathieu\",\"url\":\"https:\/\/ggba.swiss\/fr\/author\/mathieu\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer - Greater Geneva Bern area","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/","og_locale":"fr_FR","og_type":"article","og_title":"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer - Greater Geneva Bern area","og_description":"Des scientifiques de l'Universit\u00e9 et de l'Inselspital de Berne ont \u00e9tabli des mod\u00e8les de culture organo\u00efde \u00e0 partir de biopsies de tumeurs de la prostate. Il s'agit de petits groupes de cellules qui peuvent \u00eatre utilis\u00e9s pour tester l'efficacit\u00e9 de divers m\u00e9dicaments, permettant ainsi de d\u00e9terminer quel traitement sera le plus b\u00e9n\u00e9fique \u00e0 chaque patient.","og_url":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/","og_site_name":"Greater Geneva Bern area","article_published_time":"2021-03-10T11:39:45+00:00","article_modified_time":"2023-07-04T11:43:34+00:00","og_image":[{"width":630,"height":380,"url":"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg","type":"image\/jpeg"}],"author":"mathieu","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"mathieu","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#article","isPartOf":{"@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/"},"author":{"name":"mathieu","@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab"},"headline":"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer","datePublished":"2021-03-10T11:39:45+00:00","dateModified":"2023-07-04T11:43:34+00:00","mainEntityOfPage":{"@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/"},"wordCount":424,"image":{"@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg","keywords":["Education","Oncology","Personalized Medicine"],"articleSection":["Sciences de la vie"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/","url":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/","name":"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer - Greater Geneva Bern area","isPartOf":{"@id":"https:\/\/staging.ggba.swiss\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage"},"image":{"@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg","datePublished":"2021-03-10T11:39:45+00:00","dateModified":"2023-07-04T11:43:34+00:00","author":{"@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab"},"breadcrumb":{"@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#primaryimage","url":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg","contentUrl":"https:\/\/ggba.swiss\/app\/uploads\/2023\/06\/Inselspital-Bern-630x380-3.jpeg","width":630,"height":380},{"@type":"BreadcrumbList","@id":"https:\/\/ggba.swiss\/fr\/chercheurs-de-berne-ont-developpe-approche-predire-succes-therapies-contre-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ggba.swiss\/fr\/"},{"@type":"ListItem","position":2,"name":"Des chercheurs de Berne ont d\u00e9velopp\u00e9 une approche pour pr\u00e9dire le succ\u00e8s des th\u00e9rapies contre le cancer"}]},{"@type":"WebSite","@id":"https:\/\/staging.ggba.swiss\/en\/#website","url":"https:\/\/staging.ggba.swiss\/en\/","name":"Greater Geneva Bern area","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/staging.ggba.swiss\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/de091cdfd7d8bce46f9b8b1cf9d868ab","name":"mathieu","url":"https:\/\/ggba.swiss\/fr\/author\/mathieu\/"}]}},"_links":{"self":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/9626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/comments?post=9626"}],"version-history":[{"count":1,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/9626\/revisions"}],"predecessor-version":[{"id":17895,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/9626\/revisions\/17895"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/media\/9627"}],"wp:attachment":[{"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/media?parent=9626"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/categories?post=9626"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ggba.swiss\/fr\/wp-json\/wp\/v2\/tags?post=9626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}